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An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells.

Lymphoid tissue inducer (LTi) cells are associated with early development of lymph nodes and Peyer's patches. We show here that during fetal life the nuclear hormone receptor RORgamma(t) is expressed exclusively in and is required for the generation of LTi cells. RORgamma(t+) LTi cells provide essential factors, among which lymphotoxin-alpha1beta2 is necessary but not sufficient for activation of the mesenchyma in lymph node and Peyer's patch anlagen. This early LTi cell-mediated activation of lymph node and Peyer's patch mesenchyma forms the necessary platform for the subsequent development of mature lymphoid tissues.

Pubmed ID: 14691482


  • Eberl G
  • Marmon S
  • Sunshine MJ
  • Rennert PD
  • Choi Y
  • Littman DR


Nature immunology

Publication Data

January 30, 2004

Associated Grants


Mesh Terms

  • Animals
  • Embryonic and Fetal Development
  • Female
  • Flow Cytometry
  • Green Fluorescent Proteins
  • Immunohistochemistry
  • Intercellular Adhesion Molecule-1
  • Luminescent Proteins
  • Lymphoid Tissue
  • Lymphotoxin-alpha
  • Male
  • Mice
  • Mice, Knockout
  • Nuclear Receptor Subfamily 1, Group F, Member 3
  • Organogenesis
  • Receptors, Interleukin-7
  • Receptors, Retinoic Acid
  • Receptors, Thyroid Hormone
  • T-Lymphocytes, Helper-Inducer
  • Vascular Cell Adhesion Molecule-1