Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells.

Nature immunology | Jan 30, 2004

http://www.ncbi.nlm.nih.gov/pubmed/14691482

Lymphoid tissue inducer (LTi) cells are associated with early development of lymph nodes and Peyer's patches. We show here that during fetal life the nuclear hormone receptor RORgamma(t) is expressed exclusively in and is required for the generation of LTi cells. RORgamma(t+) LTi cells provide essential factors, among which lymphotoxin-alpha1beta2 is necessary but not sufficient for activation of the mesenchyma in lymph node and Peyer's patch anlagen. This early LTi cell-mediated activation of lymph node and Peyer's patch mesenchyma forms the necessary platform for the subsequent development of mature lymphoid tissues.

Pubmed ID: 14691482 RIS Download

Mesh terms: Animals | Embryonic and Fetal Development | Female | Flow Cytometry | Green Fluorescent Proteins | Immunohistochemistry | Intercellular Adhesion Molecule-1 | Luminescent Proteins | Lymphoid Tissue | Lymphotoxin-alpha | Male | Mice | Mice, Knockout | Nuclear Receptor Subfamily 1, Group F, Member 3 | Organogenesis | Receptors, Interleukin-7 | Receptors, Retinoic Acid | Receptors, Thyroid Hormone | T-Lymphocytes, Helper-Inducer | Vascular Cell Adhesion Molecule-1

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

None

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.