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The beta3 nicotinic receptor subunit: a component of alpha-conotoxin MII-binding nicotinic acetylcholine receptors that modulate dopamine release and related behaviors.

Nigrostriatal dopaminergic neurons express many nicotinic acetylcholine receptor (nAChR) subunits capable of forming multiple nAChR subtypes. These subtypes are expressed differentially along the neuron and presumably mediate diverse responses. beta3 subunit mRNA has restricted expression but is abundant in the substantia nigra and ventral tegmental areas. To investigate the potential role(s) of nicotinic receptors containing the beta3 subunit in dopaminergic tracts, we generated mice with a null mutation in the beta3 gene. We were thereby able to identify a population of beta3-dependent alpha-conotoxin MII-binding nAChRs that modulate striatal dopamine release. Changes were also observed in locomotor activity and prepulse inhibition of acoustic startle, behaviors that are controlled, in part, by nigrostriatal and mesolimbic dopaminergic activity, respectively, suggesting that beta3-containing nAChRs modulate these behaviors.

Pubmed ID: 14657161 RIS Download

Mesh terms: Animals | Behavior, Animal | Binding, Competitive | Conotoxins | Corpus Striatum | Dopamine | Dose-Response Relationship, Drug | Female | Gene Targeting | In Situ Hybridization | Ligands | Male | Mice | Mice, Knockout | Mice, Mutant Strains | Motor Activity | Neural Inhibition | Nicotine | Protein Subunits | RNA, Messenger | Rats | Receptors, Nicotinic | Reflex, Startle | Substantia Nigra | Synaptosomes

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Associated grants

  • Agency: NIA NIH HHS, Id: 2T32AG00216
  • Agency: NIDA NIH HHS, Id: DA00197
  • Agency: NIDA NIH HHS, Id: DA10156
  • Agency: NIDA NIH HHS, Id: DA12242
  • Agency: NIDA NIH HHS, Id: DA14369
  • Agency: NIMH NIH HHS, Id: MH53631
  • Agency: NINDS NIH HHS, Id: NS10830

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