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Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI.

Prefoldins (PFDs) are members of a recently identified, small-molecular weight protein family able to assemble into molecular chaperone complexes. Here we describe an unusually large member of this family, termed URI, that forms complexes with other small-molecular weight PFDs and with RPB5, a shared subunit of all three RNA polymerases. Functional analysis of the yeast and human orthologs of URI revealed that both are targets of nutrient signaling and participate in gene expression controlled by the TOR kinase. Thus, URI is a component of a signaling pathway that coordinates nutrient availability with gene expression.

Pubmed ID: 14615539


  • Gstaiger M
  • Luke B
  • Hess D
  • Oakeley EJ
  • Wirbelauer C
  • Blondel M
  • Vigneron M
  • Peter M
  • Krek W


Science (New York, N.Y.)

Publication Data

November 14, 2003

Associated Grants


Mesh Terms

  • Amino Acid Sequence
  • Amino Acids
  • Carrier Proteins
  • Cell Line
  • DNA-Binding Proteins
  • DNA-Directed RNA Polymerases
  • GATA Transcription Factors
  • Gene Expression Regulation
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Molecular Sequence Data
  • Phosphorylation
  • Protein Kinases
  • Protein Subunits
  • RNA Interference
  • Repressor Proteins
  • Saccharomyces cerevisiae
  • Saccharomyces cerevisiae Proteins
  • Signal Transduction
  • Sirolimus
  • TOR Serine-Threonine Kinases
  • Trans-Activators
  • Transcription Factors
  • Transcription, Genetic
  • Transfection