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The architecture of cognitive control in the human prefrontal cortex.

Science (New York, N.Y.) | Nov 14, 2003

The prefrontal cortex (PFC) subserves cognitive control: the ability to coordinate thoughts or actions in relation with internal goals. Its functional architecture, however, remains poorly understood. Using brain imaging in humans, we showed that the lateral PFC is organized as a cascade of executive processes from premotor to anterior PFC regions that control behavior according to stimuli, the present perceptual context, and the temporal episode in which stimuli occur, respectively. The results support an unified modular model of cognitive control that describes the overall functional organization of the human lateral PFC and has basic methodological and theoretical implications.

Pubmed ID: 14615530 RIS Download

Mesh terms: Adult | Brain Mapping | Cognition | Cues | Female | Frontal Lobe | Humans | Learning | Magnetic Resonance Imaging | Male | Memory | Mental Processes | Models, Neurological | Photic Stimulation | Prefrontal Cortex | Psychomotor Performance | Reaction Time

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