Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Isolation of human NURF: a regulator of Engrailed gene expression.

The EMBO journal | Nov 17, 2003

The modification of chromatin structure is an important regulatory mechanism for developmental gene expression. Differential expression of the mammalian ISWI genes, SNF2H and SNF2L, has suggested that they possess distinct developmental roles. Here we describe the purification and characterization of the first human SNF2L-containing complex. The subunit composition suggests that it represents the human ortholog of the Drosophila nucleosome-remodeling factor (NURF) complex. Human NURF (hNURF) is enriched in brain, and we demonstrate that it regulates human Engrailed, a homeodomain protein that regulates neuronal development in the mid-hindbrain. Furthermore, we show that hNURF potentiates neurite outgrowth in cell culture. Taken together, our data suggess a role for an ISWI complex in neuronal growth.

Pubmed ID: 14609955 RIS Download

Mesh terms: Adenosine Triphosphatases | Animals | Antigens, Nuclear | Cerebellum | DNA Helicases | DNA-Binding Proteins | Gene Expression Regulation, Developmental | Hippocampus | Homeodomain Proteins | Humans | Mice | Nerve Tissue Proteins | Neurites | Nuclear Proteins | Nucleosomes | Promoter Regions, Genetic | Transcription Factors

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

  • Agency: NIGMS NIH HHS, Id: R01 GM061204
  • Agency: NCI NIH HHS, Id: T32 CA009171
  • Agency: NCI NIH HHS, Id: CA09171-28
  • Agency: NIGMS NIH HHS, Id: GM61204

Gene Ontology (Data, Gene Annotation)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

We have not found any resources mentioned in this publication.