Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Loss of Ca2+/calmodulin kinase kinase beta affects the formation of some, but not all, types of hippocampus-dependent long-term memory.

Long-term memory (LTM) requires activation of the transcription factor cAMP-responsive element binding protein (CREB). Signaling by the Ca2+/calmodulin (CaM) kinase cascade has been implicated in CREB activation and memory consolidation processes in the hippocampus. The CaM kinase kinase beta isoforms belong to the CaM kinase cascade, and we have generated null mutant mice to investigate the role of these kinases in several forms of learning and memory. The null mutants were impaired in spatial training-induced CREB activation and spatial memory formation. Furthermore, the mutants lacked late, but not early, long-term potentiation at the hippocampal CA1 synapse, and they were impaired in LTM, but not short-term memory, for the social transmission of food preferences. We suggest that the CaM kinase kinasebeta isoforms are required for the formation of hippocampal LTM. Surprisingly, however, these kinases were not needed for contextual, trace fear, and passive avoidance LTM. Our results demonstrate that different signaling processes underlie the formation of these types of hippocampal LTM.

Pubmed ID: 14586002


  • Peters M
  • Mizuno K
  • Ris L
  • Angelo M
  • Godaux E
  • Giese KP


The Journal of neuroscience : the official journal of the Society for Neuroscience

Publication Data

October 29, 2003

Associated Grants


Mesh Terms

  • Animals
  • Behavior, Animal
  • Calcium-Calmodulin-Dependent Protein Kinase Kinase
  • Cyclic AMP Response Element-Binding Protein
  • Hippocampus
  • In Vitro Techniques
  • Isoenzymes
  • Long-Term Potentiation
  • Male
  • Memory
  • Memory, Short-Term
  • Mice
  • Mice, Neurologic Mutants
  • Protein-Serine-Threonine Kinases
  • Signal Transduction
  • Spatial Behavior
  • Time