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The DNA sequence and analysis of human chromosome 6.

Mungall AJ | Palmer SA | Sims SK | Edwards CA | Ashurst JL | Wilming L | Jones MC | Horton R | Hunt SE | Scott CE | Gilbert JG | Clamp ME | Bethel G | Milne S | Ainscough R | Almeida JP | Ambrose KD | Andrews TD | Ashwell RI | Babbage AK | Bagguley CL | Bailey J | Banerjee R | Barker DJ | Barlow KF | Bates K | Beare DM | Beasley H | Beasley O | Bird CP | Blakey S | Bray-Allen S | Brook J | Brown AJ | Brown JY | Burford DC | Burrill W | Burton J | Carder C | Carter NP | Chapman JC | Clark SY | Clark G | Clee CM | Clegg S | Cobley V | Collier RE | Collins JE | Colman LK | Corby NR | Coville GJ | Culley KM | Dhami P | Davies J | Dunn M | Earthrowl ME | Ellington AE | Evans KA | Faulkner L | Francis MD | Frankish A | Frankland J | French L | Garner P | Garnett J | Ghori MJ | Gilby LM | Gillson CJ | Glithero RJ | Grafham DV | Grant M | Gribble S | Griffiths C | Griffiths M | Hall R | Halls KS | Hammond S | Harley JL | Hart EA | Heath PD | Heathcott R | Holmes SJ | Howden PJ | Howe KL | Howell GR | Huckle E | Humphray SJ | Humphries MD | Hunt AR | Johnson CM | Joy AA | Kay M | Keenan SJ | Kimberley AM | King A | Laird GK | Langford C | Lawlor S | Leongamornlert DA | Leversha M | Lloyd CR | Lloyd DM | Loveland JE | Lovell J | Martin S | Mashreghi-Mohammadi M | Maslen GL | Matthews L | McCann OT | McLaren SJ | McLay K | McMurray A | Moore MJ | Mullikin JC | Niblett D | Nickerson T | Novik KL | Oliver K | Overton-Larty EK | Parker A | Patel R | Pearce AV | Peck AI | Phillimore B | Phillips S | Plumb RW | Porter KM | Ramsey Y | Ranby SA | Rice CM | Ross MT | Searle SM | Sehra HK | Sheridan E | Skuce CD | Smith S | Smith M | Spraggon L | Squares SL | Steward CA | Sycamore N | Tamlyn-Hall G | Tester J | Theaker AJ | Thomas DW | Thorpe A | Tracey A | Tromans A | Tubby B | Wall M | Wallis JM | West AP | White SS | Whitehead SL | Whittaker H | Wild A | Willey DJ | Wilmer TE | Wood JM | Wray PW | Wyatt JC | Young L | Younger RM | Bentley DR | Coulson A | Durbin R | Hubbard T | Sulston JE | Dunham I | Rogers J | Beck S
Nature | Oct 23, 2003

Chromosome 6 is a metacentric chromosome that constitutes about 6% of the human genome. The finished sequence comprises 166,880,988 base pairs, representing the largest chromosome sequenced so far. The entire sequence has been subjected to high-quality manual annotation, resulting in the evidence-supported identification of 1,557 genes and 633 pseudogenes. Here we report that at least 96% of the protein-coding genes have been identified, as assessed by multi-species comparative sequence analysis, and provide evidence for the presence of further, otherwise unsupported exons/genes. Among these are genes directly implicated in cancer, schizophrenia, autoimmunity and many other diseases. Chromosome 6 harbours the largest transfer RNA gene cluster in the genome; we show that this cluster co-localizes with a region of high transcriptional activity. Within the essential immune loci of the major histocompatibility complex, we find HLA-B to be the most polymorphic gene on chromosome 6 and in the human genome.

Pubmed ID: 14574404 RIS Download

Mesh terms: Animals | Chromosomes, Human, Pair 6 | Exons | Genes | Genetic Diseases, Inborn | HLA-B Antigens | Humans | Physical Chromosome Mapping | Pseudogenes | RNA, Transfer | Sequence Analysis, DNA