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Dicer is essential for mouse development.

To address the biological function of RNA interference (RNAi)-related pathways in mammals, we disrupted the gene Dicer1 in mice. Loss of Dicer1 lead to lethality early in development, with Dicer1-null embryos depleted of stem cells. Coupled with our inability to generate viable Dicer1-null embryonic stem (ES) cells, this suggests a role for Dicer, and, by implication, the RNAi machinery, in maintaining the stem cell population during early mouse development.

Pubmed ID: 14528307


  • Bernstein E
  • Kim SY
  • Carmell MA
  • Murchison EP
  • Alcorn H
  • Li MZ
  • Mills AA
  • Elledge SJ
  • Anderson KV
  • Hannon GJ


Nature genetics

Publication Data

November 31, 2003

Associated Grants


Mesh Terms

  • Amino Acid Sequence
  • Animals
  • DEAD-box RNA Helicases
  • Embryonic and Fetal Development
  • Endoribonucleases
  • Mice
  • Mice, Knockout
  • Molecular Sequence Data
  • RNA Helicases
  • RNA Interference
  • Ribonuclease III
  • Stem Cells