• Register
X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

X

Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.

No
Yes

Dicer is essential for mouse development.

To address the biological function of RNA interference (RNAi)-related pathways in mammals, we disrupted the gene Dicer1 in mice. Loss of Dicer1 lead to lethality early in development, with Dicer1-null embryos depleted of stem cells. Coupled with our inability to generate viable Dicer1-null embryonic stem (ES) cells, this suggests a role for Dicer, and, by implication, the RNAi machinery, in maintaining the stem cell population during early mouse development.

Pubmed ID: 14528307

Authors

  • Bernstein E
  • Kim SY
  • Carmell MA
  • Murchison EP
  • Alcorn H
  • Li MZ
  • Mills AA
  • Elledge SJ
  • Anderson KV
  • Hannon GJ

Journal

Nature genetics

Publication Data

November 31, 2003

Associated Grants

None

Mesh Terms

  • Amino Acid Sequence
  • Animals
  • DEAD-box RNA Helicases
  • Embryonic and Fetal Development
  • Endoribonucleases
  • Mice
  • Mice, Knockout
  • Molecular Sequence Data
  • RNA Helicases
  • RNA Interference
  • Ribonuclease III
  • Stem Cells