Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

CB1 cannabinoid receptors and on-demand defense against excitotoxicity.

Science (New York, N.Y.) | Oct 3, 2003

http://www.ncbi.nlm.nih.gov/pubmed/14526074

Abnormally high spiking activity can damage neurons. Signaling systems to protect neurons from the consequences of abnormal discharge activity have been postulated. We generated conditional mutant mice that lack expression of the cannabinoid receptor type 1 in principal forebrain neurons but not in adjacent inhibitory interneurons. In mutant mice,the excitotoxin kainic acid (KA) induced excessive seizures in vivo. The threshold to KA-induced neuronal excitation in vitro was severely reduced in hippocampal pyramidal neurons of mutants. KA administration rapidly raised hippocampal levels of anandamide and induced protective mechanisms in wild-type principal hippocampal neurons. These protective mechanisms could not be triggered in mutant mice. The endogenous cannabinoid system thus provides on-demand protection against acute excitotoxicity in central nervous system neurons.

Pubmed ID: 14526074 RIS Download

Mesh terms: Animals | Arachidonic Acids | Brain | Brain-Derived Neurotrophic Factor | Cannabinoids | Endocannabinoids | Epilepsy | Excitatory Amino Acid Agonists | Excitatory Postsynaptic Potentials | Furans | Gene Expression Regulation | Genes, Immediate-Early | Glutamic Acid | Glycerides | Hippocampus | In Vitro Techniques | Kainic Acid | Male | Mice | Mice, Inbred C57BL | Mice, Knockout | Mice, Transgenic | Mitogen-Activated Protein Kinases | Mutation | Neurons | Neuroprotective Agents | Piperidines | Polyunsaturated Alkamides | Prosencephalon | Pyrazoles | Receptors, Cannabinoid | Receptors, Drug | Signal Transduction | gamma-Aminobutyric Acid

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

None

Mouse Genome Informatics (Data, Gene Annotation)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.