• Register
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.


Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.


Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease.

Transforming growth factor-beta 1 (TGF-beta 1) is a multifunctional growth factor that has profound regulatory effects on many developmental and physiological processes. Disruption of the TGF-beta 1 gene by homologous recombination in murine embryonic stem cells enables mice to be generated that carry the disrupted allele. Animals homozygous for the mutated TGF-beta 1 allele show no gross developmental abnormalities, but about 20 days after birth they succumb to a wasting syndrome accompanied by a multifocal, mixed inflammatory cell response and tissue necrosis, leading to organ failure and death. TGF-beta 1-deficient mice may be valuable models for human immune and inflammatory disorders, including autoimmune diseases, transplant rejection and graft versus host reactions.

Pubmed ID: 1436033


  • Shull MM
  • Ormsby I
  • Kier AB
  • Pawlowski S
  • Diebold RJ
  • Yin M
  • Allen R
  • Sidman C
  • Proetzel G
  • Calvin D



Publication Data

October 22, 1992

Associated Grants

  • Agency: NICHD NIH HHS, Id: R01 HD026471

Mesh Terms

  • Animals
  • Base Sequence
  • Cytokines
  • Gene Expression
  • Genes
  • Homozygote
  • Inflammation
  • Leukocyte Count
  • Mice
  • Mice, Transgenic
  • Molecular Sequence Data
  • Mutagenesis, Insertional
  • Necrosis
  • Oligodeoxyribonucleotides
  • Polymerase Chain Reaction
  • RNA, Messenger
  • Restriction Mapping
  • Transforming Growth Factor beta