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Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease.

Nature | Oct 22, 1992

Transforming growth factor-beta 1 (TGF-beta 1) is a multifunctional growth factor that has profound regulatory effects on many developmental and physiological processes. Disruption of the TGF-beta 1 gene by homologous recombination in murine embryonic stem cells enables mice to be generated that carry the disrupted allele. Animals homozygous for the mutated TGF-beta 1 allele show no gross developmental abnormalities, but about 20 days after birth they succumb to a wasting syndrome accompanied by a multifocal, mixed inflammatory cell response and tissue necrosis, leading to organ failure and death. TGF-beta 1-deficient mice may be valuable models for human immune and inflammatory disorders, including autoimmune diseases, transplant rejection and graft versus host reactions.

Pubmed ID: 1436033 RIS Download

Mesh terms: Animals | Base Sequence | Cytokines | Gene Expression | Genes | Homozygote | Inflammation | Leukocyte Count | Mice | Mice, Transgenic | Molecular Sequence Data | Mutagenesis, Insertional | Necrosis | Oligodeoxyribonucleotides | Polymerase Chain Reaction | RNA, Messenger | Restriction Mapping | Transforming Growth Factor beta

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Associated grants

  • Agency: NICHD NIH HHS, Id: R01 HD026471

Mouse Genome Informatics (Data, Gene Annotation)

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