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Effects of an Rb mutation in the mouse.

The retinoblastoma gene is mutated in several types of human cancer and is the best characterized of the tumour-suppressor genes. A mouse strain has been constructed in which one allele of Rb is disrupted. These heterozygous animals are not predisposed to retinoblastoma, but some display pituitary tumours arising from cells in which the wild-type Rb allele is absent. Embryos homozygous for the mutation die between days 14 and 15 of gestation, exhibiting neuronal cell death and defective erythropoiesis.

Pubmed ID: 1406933

Authors

  • Jacks T
  • Fazeli A
  • Schmitt EM
  • Bronson RT
  • Goodell MA
  • Weinberg RA

Journal

Nature

Publication Data

September 24, 1992

Associated Grants

None

Mesh Terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cell Death
  • Erythropoiesis
  • Eye Neoplasms
  • Genes, Retinoblastoma
  • Heterozygote
  • Homozygote
  • Humans
  • Liver
  • Mice
  • Mice, Mutant Strains
  • Molecular Sequence Data
  • Mutation
  • Neurons
  • Phenotype
  • Restriction Mapping
  • Retinoblastoma