Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Deficient hippocampal long-term potentiation in alpha-calcium-calmodulin kinase II mutant mice.

Science (New York, N.Y.) | Jul 10, 1992

http://www.ncbi.nlm.nih.gov/pubmed/1378648

As a first step in a program to use genetically altered mice in the study of memory mechanisms, mutant mice were produced that do not express the alpha-calcium-calmodulin-dependent kinase II (alpha-CaMKII). The alpha-CaMKII is highly enriched in postsynaptic densities of hippocampus and neocortex and may be involved in the regulation of long-term potentiation (LTP). Such mutant mice exhibited mostly normal behaviors and presented no obvious neuroanatomical defects. Whole cell recordings reveal that postsynaptic mechanisms, including N-methyl-D-aspartate (NMDA) receptor function, are intact. Despite normal postsynaptic mechanisms, these mice are deficient in their ability to produce LTP and are therefore a suitable model for studying the relation between LTP and learning processes.

Pubmed ID: 1378648 RIS Download

Mesh terms: Animals | Behavior, Animal | Blotting, Northern | Blotting, Southern | Calcium-Calmodulin-Dependent Protein Kinases | Chromosome Mapping | DNA | Electrophysiology | Female | Hippocampus | Learning | Male | Mice | Mice, Inbred BALB C | Mice, Mutant Strains | Mutagenesis, Site-Directed | Plasmids | Protein Kinases | RNA | Receptors, N-Methyl-D-Aspartate | Synapses | Transfection

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

  • Agency: NINDS NIH HHS, Id: 5 R01 NS 12961-17

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.