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brahma: a regulator of Drosophila homeotic genes structurally related to the yeast transcriptional activator SNF2/SWI2.

The brahma (brm) gene is required for the activation of multiple homeotic genes in Drosophila. Loss-of-function brm mutations suppress mutations in Polycomb, a repressor of homeotic genes, and cause developmental defects similar to those arising from insufficient expression of the homeotic genes of the Antennapedia and Bithorax complexes. The brm gene encodes a 1638 residue protein that is similar to SNF2/SWI2, a protein involved in transcriptional activation in yeast, suggesting possible models for the role of brm in the transcriptional activation of homeotic genes. In addition, both brm and SNF2 contain a 77 amino acid motif that is found in other Drosophila, yeast, and human regulatory proteins and may be characteristic of a new family of regulatory proteins.

Pubmed ID: 1346755

Authors

  • Tamkun JW
  • Deuring R
  • Scott MP
  • Kissinger M
  • Pattatucci AM
  • Kaufman TC
  • Kennison JA

Journal

Cell

Publication Data

February 7, 1992

Associated Grants

None

Mesh Terms

  • Adenosine Triphosphatases
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cloning, Molecular
  • DNA-Binding Proteins
  • Drosophila
  • Gene Library
  • Genes
  • Genes, Homeobox
  • Genes, Regulator
  • Molecular Sequence Data
  • Morphogenesis
  • Nuclear Proteins
  • Saccharomyces cerevisiae
  • Saccharomyces cerevisiae Proteins
  • Sequence Alignment
  • Trans-Activators
  • Transcription Factors
  • Transcription, Genetic