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Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease.

The effect of mammary gland-specific expression of the polyomavirus middle T antigen was examined by establishing lines of transgenic mice that carry the middle T oncogene under the transcriptional control of the mouse mammary tumor virus promoter/enhancer. By contrast to most transgenic strains carrying activated oncogenes, expression of polyomavirus middle T antigen resulted in the widespread transformation of the mammary epithelium and the rapid production of multifocal mammary adenocarcinomas. Interestingly, the majority of the tumor-bearing transgenic mice developed secondary metastatic tumors in the lung. Taken together, these results suggest that middle T antigen acts as a potent oncogene in the mammary epithelium and that cells that express it possess an enhanced metastatic potential.

Pubmed ID: 1312220


  • Guy CT
  • Cardiff RD
  • Muller WJ


Molecular and cellular biology

Publication Data

March 13, 1992

Associated Grants

  • Agency: NCI NIH HHS, Id: R01-CAS4285

Mesh Terms

  • Animals
  • Antigens, Polyomavirus Transforming
  • Cloning, Molecular
  • Epithelium
  • Female
  • Male
  • Mammary Neoplasms, Experimental
  • Mammary Tumor Virus, Mouse
  • Mice
  • Mice, Transgenic
  • Models, Genetic
  • Oncogenes
  • Organ Specificity