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Ephrin-B2 and EphB1 mediate retinal axon divergence at the optic chiasm.

Neuron | Sep 11, 2003

http://www.ncbi.nlm.nih.gov/pubmed/12971893

In animals with binocular vision, retinal ganglion cell (RGC) axons either cross or avoid the midline at the optic chiasm. Here, we show that ephrin-Bs in the chiasm region direct the divergence of retinal axons through the selective repulsion of a subset of RGCs that express EphB1. Ephrin-B2 is expressed at the mouse chiasm midline as the ipsilateral projection is generated and is selectively inhibitory to axons from ventrotemporal (VT) retina, where ipsilaterally projecting RGCs reside. Moreover, blocking ephrin-B2 function in vitro rescues the inhibitory effect of chiasm cells and eliminates the ipsilateral projection in the semiintact mouse visual system. A receptor for ephrin-B2, EphB1, is found exclusively in regions of retina that give rise to the ipsilateral projection. EphB1 null mice exhibit a dramatically reduced ipsilateral projection, suggesting that this receptor contributes to the formation of the ipsilateral retinal projection, most likely through its repulsive interaction with ephrin-B2.

Pubmed ID: 12971893 RIS Download

Mesh terms: Animals | Axons | Cells, Cultured | Ephrin-B1 | Ephrin-B2 | Female | Gene Expression Regulation, Developmental | Humans | Mice | Mice, Inbred C57BL | Mice, Knockout | Optic Chiasm | Pregnancy | Retina | Retinal Ganglion Cells | Xenopus

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Associated grants

  • Agency: Wellcome Trust, Id: 070568
  • Agency: PHS HHS, Id: P030532
  • Agency: NEI NIH HHS, Id: R01 EY12736
  • Agency: NEI NIH HHS, Id: T32 EY13933

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