• Register
X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

X

Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.

No
Yes

Cingulate hypoactivity in cocaine users during a GO-NOGO task as revealed by event-related functional magnetic resonance imaging.

Although extensive evidence exists for the reinforcing properties of drugs of abuse such as cocaine, relatively less research has addressed the functional neuroanatomical correlates of the cognitive sequelae of these drugs. We present a functional magnetic resonance imaging study of a GO-NOGO task in which successful performance required prepotent behaviors to be inhibited. Significant cingulate, pre-supplementary motor and insula hypoactivity was observed for both successful NOGOs and errors of commission in chronic cocaine users relative to cocaine-naive controls. This attenuated response, in the presence of comparable activation levels in other task-related cortical areas, suggests cortical and psychological specificity in the locus of drug abuse-related cognitive dysfunction. The results suggest that addiction may be accompanied by a disruption of brain structures critical for the higher-order, cognitive control of behavior.

Pubmed ID: 12944513

Authors

  • Kaufman JN
  • Ross TJ
  • Stein EA
  • Garavan H

Journal

The Journal of neuroscience : the official journal of the Society for Neuroscience

Publication Data

August 27, 2003

Associated Grants

  • Agency: NIDA NIH HHS, Id: DA14100
  • Agency: NCRR NIH HHS, Id: M01 RR00058

Mesh Terms

  • Adult
  • Behavior
  • Cocaine-Related Disorders
  • Cognition
  • Female
  • Gyrus Cinguli
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Neural Inhibition
  • Neuropsychological Tests
  • Photic Stimulation