Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice.

Nature genetics | Sep 29, 2003

http://www.ncbi.nlm.nih.gov/pubmed/12923533

We targeted the locus encoding the cyclin-dependent kinase 2 (CDK2) by homologous recombination in mouse embryonic stem (ES) cells. Embryonic fibroblasts lacking CDK2 proliferate normally and become immortal after continuous passage in culture. Elimination of a conditional Cdk2 allele in immortal cells does not have a significant effect on proliferation. Cdk2-/- mice are viable and survive for up to two years, indicating that CDK2 is also dispensable for proliferation and survival of most cell types. But CDK2 is essential for completion of prophase I during meiotic cell division in male and female germ cells, an unforeseen role for this cell cycle kinase.

Pubmed ID: 12923533 RIS Download

Mesh terms: Animals | CDC2-CDC28 Kinases | Cells, Cultured | Cyclin-Dependent Kinase 2 | Cyclin-Dependent Kinases | Female | Fibroblasts | Male | Meiosis | Mice | Mice, Knockout | Mitosis | Oocytes | Ovary | Protein-Serine-Threonine Kinases | Serial Passage | Spermatogenesis | Testis

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

None

Mouse Genome Informatics (Data, Gene Annotation)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.