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Cloning, functional study and comparative mapping of Luzp2 to mouse chromosome 7 and human chromosome 11p13-11p14.

A novel leucine-zipper gene, leucine zipper protein 2 (Luzp2), has been cloned as part of an aberrant deletion-fusion transcript in the chromosomal interval between Gas2 and Herc2 on mouse Chromosome 7 (Chr 7). Luzp2 is normally expressed only in brain and spinal cord. The human homolog of Luzp2 maps to Chr 11p13-11p14 by radiation-hybrid mapping and is deleted in some patients with Wilms tumor-Aniridia-Genitourinary anomalies-mental Retardation (WAGR) syndrome. Disruption of Luzp2 by gene targeting in mice did not result in any obvious abnormal phenotypes.

Pubmed ID: 12856284


  • Wu M
  • Michaud EJ
  • Johnson DK


Mammalian genome : official journal of the International Mammalian Genome Society

Publication Data

May 14, 2003

Associated Grants


Mesh Terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Blotting, Northern
  • Chromosome Deletion
  • Chromosome Mapping
  • Chromosomes, Human, Pair 11
  • Cloning, Molecular
  • DNA Mutational Analysis
  • DNA Primers
  • DNA-Binding Proteins
  • Female
  • Gene Expression Regulation, Developmental
  • Gene Targeting
  • Humans
  • Leucine Zippers
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Molecular Sequence Data
  • Phenotype
  • Polymerase Chain Reaction
  • Radiation Hybrid Mapping
  • Ribonuclease, Pancreatic
  • Tumor Cells, Cultured
  • WAGR Syndrome