Cloning, functional study and comparative mapping of Luzp2 to mouse chromosome 7 and human chromosome 11p13-11p14.
A novel leucine-zipper gene, leucine zipper protein 2 (Luzp2), has been cloned as part of an aberrant deletion-fusion transcript in the chromosomal interval between Gas2 and Herc2 on mouse Chromosome 7 (Chr 7). Luzp2 is normally expressed only in brain and spinal cord. The human homolog of Luzp2 maps to Chr 11p13-11p14 by radiation-hybrid mapping and is deleted in some patients with Wilms tumor-Aniridia-Genitourinary anomalies-mental Retardation (WAGR) syndrome. Disruption of Luzp2 by gene targeting in mice did not result in any obvious abnormal phenotypes.
Pubmed ID: 12856284 RIS Download
Amino Acid Sequence | Animals | Base Sequence | Blotting, Northern | Chromosome Deletion | Chromosome Mapping | Chromosomes, Human, Pair 11 | Cloning, Molecular | DNA Mutational Analysis | DNA Primers | DNA-Binding Proteins | Female | Gene Expression Regulation, Developmental | Gene Targeting | Humans | Leucine Zippers | Male | Mice | Mice, Inbred C57BL | Mice, Knockout | Molecular Sequence Data | Phenotype | Polymerase Chain Reaction | Radiation Hybrid Mapping | Ribonuclease, Pancreatic | Tumor Cells, Cultured | WAGR Syndrome