Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a.

Science (New York, N.Y.) | Jul 11, 2003

http://www.ncbi.nlm.nih.gov/pubmed/12855809

Foxo transcription factors have been implicated in diverse biological processes, including metabolism, cellular stress responses, and aging. Here, we show that Foxo3a-/- female mice exhibit a distinctive ovarian phenotype of global follicular activation leading to oocyte death, early depletion of functional ovarian follicles, and secondary infertility. Foxo3a thus functions at the earliest stages of follicular growth as a suppressor of follicular activation. In addition to providing a molecular entry point for studying the regulation of follicular growth, these results raise the possibility that accelerated follicular initiation plays a role in premature ovarian failure, a common cause of infertility and premature aging in women.

Pubmed ID: 12855809 RIS Download

Mesh terms: Animals | Apoptosis | Cell Size | DNA-Binding Proteins | Female | Follicle Stimulating Hormone | Follicular Atresia | Forkhead Transcription Factors | Gene Targeting | Granulosa Cells | Humans | Infertility, Female | Luteinizing Hormone | Male | Mice | Mice, Knockout | Oocytes | Ovarian Follicle | Ovary | Ovulation | Primary Ovarian Insufficiency | Sexual Maturation | Superovulation | Transcription Factors

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

  • Agency: PHS HHS, Id: K08

Mouse Genome Informatics (Data, Gene Annotation)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.