Costimulation through the inducible costimulator (ICOS) and its ligand (ICOSL) is essential for T cell-dependent B cell responses, but the cellular and temporal dynamics underlying its in vivo effects are poorly defined. Here we have shown that Icosl(-/-) and Icos(-/-) mice had similar phenotypes and that ICOS-ICOSL costimulation modulated the early but not late phases of IgG1 affinity maturation. Exploiting the adoptive transfer of T or B cells from primed Icosl(-/-) mice, we provided genetic evidence that costimulation through ICOSL was essential for primary but not secondary helper T cell responses and for the control of both T and B cell activities, resulting in T cell-dependent IgG1 production.
Pubmed ID: 12833154 RIS Download
Mesh terms: Animals | Antigens, Differentiation, T-Lymphocyte | B-Lymphocytes | Gene Deletion | Immunoglobulin G | Inducible T-Cell Co-Stimulator Ligand | Inducible T-Cell Co-Stimulator Protein | Lymphocyte Cooperation | Mice | Proteins | T-Lymphocytes, Helper-Inducer
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