Using fMRI, we sought to determine whether the posterior, superior portion of Broca's area performs operations on phoneme segments specifically or implements processes general to sequencing discrete units. Twelve healthy volunteers performed two sequence manipulation tasks and one matching task, using strings of syllables and hummed notes. The posterior portion of Broca's area responded specifically to the sequence manipulation tasks, independent of whether the stimuli were composed of phonemes or hummed notes. In contrast, the left supramarginal gyrus was somewhat more specific to sequencing phoneme segments. These results suggest a functional dissociation of the canonical left hemisphere language regions encompassing the "phonological loop," with the left posterior inferior frontal gyrus responding not to the sound structure of language but rather to sequential operations that may underlie the ability to form words out of dissociable elements.
Pubmed ID: 12797966 RIS Download
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Software package for analysis of brain imaging data sequences. Sequences can be a series of images from different cohorts, or time-series from same subject. Current release is designed for analysis of fMRI, PET, SPECT, EEG and MEG.
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