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The Cdc14 phosphatase and the FEAR network control meiotic spindle disassembly and chromosome segregation.

Developmental cell | May 9, 2003

http://www.ncbi.nlm.nih.gov/pubmed/12737806

During meiosis, DNA replication is followed by two consecutive rounds of chromosome segregation. Cells lacking the protein phosphatase CDC14 or its regulators, SPO12 and SLK19, undergo only a single meiotic division, with some chromosomes segregating reductionally and others equationally. We find that this abnormal chromosome behavior is due to an uncoupling of meiotic events. Anaphase I spindle disassembly is delayed in cdc14-1, slk19Delta, or spo12Delta mutants, but the chromosome segregation cycle continues, so that both meiotic chromosome segregation phases take place on the persisting meiosis I spindle. Our results show that Cdc14, Slk19, and Spo12 are not only required for meiosis I spindle disassembly but also play a pivotal role in establishing two consecutive chromosome segregation phases, a key feature of the meiotic cell cycle.

Pubmed ID: 12737806 RIS Download

Mesh terms: Anaphase | Cell Cycle Proteins | Cell Nucleolus | Chromatids | Chromosome Segregation | Fungal Proteins | Meiosis | Microtubule-Associated Proteins | Mutation | Nuclear Proteins | Protein Tyrosine Phosphatases | Saccharomyces cerevisiae | Saccharomyces cerevisiae Proteins | Time Factors