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Requirement of Cks2 for the first metaphase/anaphase transition of mammalian meiosis.

We generated mice lacking Cks2, one of two mammalian homologs of the yeast Cdk1-binding proteins, Suc1 and Cks1, and found them to be viable but sterile in both sexes. Sterility is due to failure of both male and female germ cells to progress past the first meiotic metaphase. The chromosomal events up through the end of prophase I are normal in both CKS2-/- males and females, suggesting that the phenotype is due directly to failure to enter anaphase and not a consequence of a checkpoint-mediated metaphase I arrest.

Pubmed ID: 12714746


  • Spruck CH
  • de Miguel MP
  • Smith AP
  • Ryan A
  • Stein P
  • Schultz RM
  • Lincoln AJ
  • Donovan PJ
  • Reed SI


Science (New York, N.Y.)

Publication Data

April 25, 2003

Associated Grants

  • Agency: NCI NIH HHS, Id: CA74224
  • Agency: NICHD NIH HHS, Id: HD22681
  • Agency: NICHD NIH HHS, Id: HD38252

Mesh Terms

  • Anaphase
  • Animals
  • Apoptosis
  • CDC2-CDC28 Kinases
  • CDC28 Protein Kinase, S cerevisiae
  • Chromosome Segregation
  • Cyclin A
  • Cyclin B
  • Epididymis
  • Female
  • Gene Targeting
  • In Situ Hybridization
  • Infertility, Female
  • Infertility, Male
  • Male
  • Meiosis
  • Metaphase
  • Mice
  • Mutation
  • Oocytes
  • Ovary
  • RNA, Messenger
  • Recombination, Genetic
  • Spermatocytes
  • Spermatogenesis
  • Testis