• Register
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.


Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.


IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.

The transcription factors interferon regulatory factor 3 (IRF3) and NF-kappaB are required for the expression of many genes involved in the innate immune response. Viral infection, or the binding of double-stranded RNA to Toll-like receptor 3, results in the coordinate activation of IRF3 and NF-kappaB. Activation of IRF3 requires signal-dependent phosphorylation, but little is known about the signaling pathway or kinases involved. Here we report that the noncanonical IkappaB kinase homologs, IkappaB kinase-epsilon (IKKepsilon) and TANK-binding kinase-1 (TBK1), which were previously implicated in NF-kappaB activation, are also essential components of the IRF3 signaling pathway. Thus, IKKepsilon and TBK1 have a pivotal role in coordinating the activation of IRF3 and NF-kappaB in the innate immune response.

Pubmed ID: 12692549


  • Fitzgerald KA
  • McWhirter SM
  • Faia KL
  • Rowe DC
  • Latz E
  • Golenbock DT
  • Coyle AJ
  • Liao SM
  • Maniatis T


Nature immunology

Publication Data

May 29, 2003

Associated Grants

  • Agency: NIAID NIH HHS, Id: R01 AI20642
  • Agency: NIGMS NIH HHS, Id: R01 GM54060

Mesh Terms

  • Adaptor Proteins, Vesicular Transport
  • Chemokine CCL5
  • DNA-Binding Proteins
  • Drosophila Proteins
  • Gene Expression Regulation
  • Humans
  • I-kappa B Kinase
  • Immunity, Innate
  • Interferon Regulatory Factor-3
  • Interferon-beta
  • Membrane Glycoproteins
  • NF-kappa B
  • Protein-Serine-Threonine Kinases
  • RNA Interference
  • Receptors, Cell Surface
  • Signal Transduction
  • Toll-Like Receptor 3
  • Toll-Like Receptors
  • Transcription Factors
  • Virus Diseases