• Register
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.


Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.


The posterior cingulate and medial prefrontal cortex mediate the anticipatory allocation of spatial attention.

The purpose of this study was to identify brain regions underlying internally generated anticipatory biases toward locations where significant events are expected to occur. Subjects fixated centrally and responded to peripheral targets preceded by a spatially valid (predictive), invalid (misleading), or neutral central cue while undergoing fMRI scanning. In some validly cued trials, reaction time was significantly shorter than in trials with neutral cues, indicating that the cue had successfully induced a spatial redistribution of motivational valence, manifested as expectancy. The largest cue benefits led to selectively greater activations within the posterior cingulate and medial prefrontal cortex. These two areas thus appear to establish a neural interface between attention and motivation. An inverse relationship to cue benefit was seen in the parietal cortex, suggesting that spatial expectancy may entail the inhibition of attention-related areas to reduce distractibility by events at irrelevant locations.

Pubmed ID: 12667840


  • Small DM
  • Gitelman DR
  • Gregory MD
  • Nobre AC
  • Parrish TB
  • Mesulam MM



Publication Data

March 1, 2003

Associated Grants

  • Agency: NIA NIH HHS, Id: AG138541
  • Agency: NIA NIH HHS, Id: K23 AG000940
  • Agency: NIA NIH HHS, Id: K23 AG000940-04
  • Agency: NIA NIH HHS, Id: K23 AG00940-02
  • Agency: NINDS NIH HHS, Id: NS30863-03

Mesh Terms

  • Adult
  • Arousal
  • Attention
  • Brain Mapping
  • Female
  • Gyrus Cinguli
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Motivation
  • Nerve Net
  • Orientation
  • Parietal Lobe
  • Pattern Recognition, Visual
  • Prefrontal Cortex
  • Psychomotor Performance
  • Reaction Time
  • Set (Psychology)