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The posterior cingulate and medial prefrontal cortex mediate the anticipatory allocation of spatial attention.

NeuroImage | Mar 1, 2003

http://www.ncbi.nlm.nih.gov/pubmed/12667840

The purpose of this study was to identify brain regions underlying internally generated anticipatory biases toward locations where significant events are expected to occur. Subjects fixated centrally and responded to peripheral targets preceded by a spatially valid (predictive), invalid (misleading), or neutral central cue while undergoing fMRI scanning. In some validly cued trials, reaction time was significantly shorter than in trials with neutral cues, indicating that the cue had successfully induced a spatial redistribution of motivational valence, manifested as expectancy. The largest cue benefits led to selectively greater activations within the posterior cingulate and medial prefrontal cortex. These two areas thus appear to establish a neural interface between attention and motivation. An inverse relationship to cue benefit was seen in the parietal cortex, suggesting that spatial expectancy may entail the inhibition of attention-related areas to reduce distractibility by events at irrelevant locations.

Pubmed ID: 12667840 RIS Download

Mesh terms: Adult | Arousal | Attention | Brain Mapping | Female | Gyrus Cinguli | Humans | Magnetic Resonance Imaging | Male | Motivation | Nerve Net | Orientation | Parietal Lobe | Pattern Recognition, Visual | Prefrontal Cortex | Psychomotor Performance | Reaction Time | Set (Psychology)

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Associated grants

  • Agency: NIA NIH HHS, Id: AG138541
  • Agency: NIA NIH HHS, Id: K23 AG000940
  • Agency: NIA NIH HHS, Id: K23 AG000940-04
  • Agency: NIA NIH HHS, Id: K23 AG00940-02
  • Agency: NINDS NIH HHS, Id: NS30863-03

SumsDB (Data, Activation Foci)

NeuroSynth (Data, Activation Foci)

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