Mammals detect temperature with specialized neurons in the peripheral nervous system. Four TRPV-class channels have been implicated in sensing heat, and one TRPM-class channel in sensing cold. The combined range of temperatures that activate these channels covers a majority of the relevant physiological spectrum sensed by most mammals, with a significant gap in the noxious cold range. Here, we describe the characterization of ANKTM1, a cold-activated channel with a lower activation temperature compared to the cold and menthol receptor, TRPM8. ANKTM1 is a distant family member of TRP channels with very little amino acid similarity to TRPM8. It is found in a subset of nociceptive sensory neurons where it is coexpressed with TRPV1/VR1 (the capsaicin/heat receptor) but not TRPM8. Consistent with the expression of ANKTM1, we identify noxious cold-sensitive sensory neurons that also respond to capsaicin but not to menthol.
Pubmed ID: 12654248 RIS Download
Mesh terms: Amino Acid Sequence | Animals | Ankyrins | CHO Cells | Calcium Channels | Capsaicin | Cells, Cultured | Cold Temperature | Cricetinae | Female | Membrane Proteins | Mice | Molecular Sequence Data | Nerve Tissue Proteins | Neurons, Afferent | Nociceptors | Protein Structure, Tertiary | Rats | Rats, Sprague-Dawley | TRPC Cation Channels | Thermoreceptors | Transient Receptor Potential Channels
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