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Enhanced interleukin (IL)-13 responses in mice lacking IL-13 receptor alpha 2.

Interleukin (IL)-13 has recently been shown to play important and unique roles in asthma, parasite immunity, and tumor recurrence. At least two distinct receptor components, IL-4 receptor (R)alpha and IL-13Ralpha1, mediate the diverse actions of IL-13. We have recently described an additional high affinity receptor for IL-13, IL-13Ralpha2, whose function in IL-13 signaling is unknown. To better appreciate the functional importance of IL-13Ralpha2, mice deficient in IL-13Ralpha2 were generated by gene targeting. Serum immunoglobulin E levels were increased in IL-13Ralpha2-/- mice despite the fact that serum IL-13 was absent and immune interferon gamma production increased compared with wild-type mice. IL-13Ralpha2-deficient mice display increased bone marrow macrophage progenitor frequency and decreased tissue macrophage nitric oxide and IL-12 production in response to lipopolysaccharide. These results are consistent with a phenotype of enhanced IL-13 responsiveness and demonstrate a role for endogenous IL-13 and IL-13Ralpha2 in regulating immune responses in wild-type mice.

Pubmed ID: 12642602

Authors

  • Wood N
  • Whitters MJ
  • Jacobson BA
  • Witek J
  • Sypek JP
  • Kasaian M
  • Eppihimer MJ
  • Unger M
  • Tanaka T
  • Goldman SJ
  • Collins M
  • Donaldson DD
  • Grusby MJ

Journal

The Journal of experimental medicine

Publication Data

March 17, 2003

Associated Grants

None

Mesh Terms

  • Animals
  • Cells, Cultured
  • Fibroblasts
  • Gene Targeting
  • Immunoglobulins
  • Interferon-gamma
  • Interleukin-13
  • Interleukin-13 Receptor alpha1 Subunit
  • Macrophages
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Receptors, Interleukin
  • Receptors, Interleukin-13
  • Receptors, Interleukin-4
  • STAT6 Transcription Factor
  • Signal Transduction
  • Stem Cells
  • Trans-Activators