Our hosting provider will be performing UPS maintenance on Tuesday, Oct 25, 2016 between 8 AM and 5 PM PDT. SciCrunch searching services will be down during this time.

Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Persistence and brain circuitry.


The orbitofrontal and adjacent medial prefrontal cortex may play an important role in normal social functioning and affect modulation. Recent anatomical studies of this area of the prefrontal cortex have demonstrated a striking correspondence of fine-grained architectonic partitioning schemes in humans and nonhuman primates. This finding allows neurophysiological recording and anatomical connectivity data in animals to be considered together with functional imaging data and lesion studies in humans. In a functional MRI study, we show that individual differences in Persistence, a dimensional trait assessed with a seven-factor personality model, may be linked to specific areas in the lateral orbital and medial prefrontal cortex and the ventral striatum. These areas are part of an anatomical circuit that has been defined in nonhuman primates and has been implicated in functions related to behavioral persistence. These findings represent a fresh approach to linking normal individual differences in personality and behavior to specific neuronal structures and subsystems.

Pubmed ID: 12626765


  • Gusnard DA
  • Ollinger JM
  • Shulman GL
  • Cloninger CR
  • Price JL
  • Van Essen DC
  • Raichle ME


Proceedings of the National Academy of Sciences of the United States of America

Publication Data

March 18, 2003

Associated Grants

  • Agency: NIDA NIH HHS, Id: DA 07261
  • Agency: NIDCD NIH HHS, Id: DC 00093
  • Agency: NIMH NIH HHS, Id: MH 60974
  • Agency: NIMH NIH HHS, Id: MH 62130
  • Agency: NINDS NIH HHS, Id: NS 06833
  • Agency: NIMH NIH HHS, Id: R01 MH060879

Mesh Terms

  • Adult
  • Animals
  • Female
  • Haplorhini
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Personality
  • Prefrontal Cortex
  • Social Behavior
  • Species Specificity