The molecular properties that characterize CD4+CD25+ regulatory T cells (TR cells) remain elusive. Absence of the transcription factor Scurfin (also known as forkhead box P3 and encoded by Foxp3) causes a rapidly fatal lymphoproliferative disease, similar to that seen in mice lacking cytolytic T lymphocyte-associated antigen 4 (CTLA-4). Here we show that Foxp3 is highly expressed by T(R) cells and is associated with T(R) cell activity and phenotype. Scurfin-deficient mice lack T(R) cells, whereas mice that overexpress Foxp3 possess more T(R) cells. In Foxp3-overexpressing mice, both CD4+CD25- and CD4-CD8+ T cells show suppressive activity and CD4+CD25- cells express glucocorticoid-induced tumor-necrosis factor receptor-related (GITR) protein. The forced expression of Foxp3 also delays disease in CTLA-4-/- mice, indicating that the Scurfin and CTLA-4 pathways may intersect and providing further insight into the T(R) cell lineage.
Pubmed ID: 12612581 RIS Download
Mesh terms: Abatacept | Animals | Antigens, CD | Antigens, Differentiation | CD4-Positive T-Lymphocytes | CTLA-4 Antigen | DNA-Binding Proteins | Forkhead Transcription Factors | Glucocorticoid-Induced TNFR-Related Protein | Immunoconjugates | Interleukin-10 | Mice | Mice, Transgenic | Receptors, Interleukin-2 | Receptors, Nerve Growth Factor | Receptors, Tumor Necrosis Factor | Transforming Growth Factor beta
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