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Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development.

The nature of signals that govern the development of immunoglobulin heavy chain-dependent B cells is largely unknown. Using mice deficient for the B cell-expressed Src-family protein tyrosine kinases (SFKs) Blk, Fyn and Lyn, we show an essential role of these kinases in pre-B cell receptor (pre-BCR)- mediated NF-kappaB activation and B cell development. This signaling defect is SFK specific, as a deficiency in Syk, which controls pre-B cell development, does not affect NF-kappaB induction. Impaired NF-kappaB induction was overcome by the activation of protein kinase C (PKC)-lambda, thus suggesting the involvement of PKC-lambda in pre-BCR-mediated SFK-dependent activation of NF-kappaB. Our data show the existence of a functionally distinct SFK signaling module responsible for pre-BCR-mediated NF-kappaB activation and B cell development.

Pubmed ID: 12563261

Authors

  • Saijo K
  • Schmedt C
  • Su IH
  • Karasuyama H
  • Lowell CA
  • Reth M
  • Adachi T
  • Patke A
  • Santana A
  • Tarakhovsky A

Journal

Nature immunology

Publication Data

March 26, 2003

Associated Grants

  • Agency: NIAID NIH HHS, Id: AI053545-01
  • Agency: NIDDK NIH HHS, Id: DK58066
  • Agency: NHLBI NIH HHS, Id: HL54476

Mesh Terms

  • Animals
  • B-Lymphocytes
  • Cell Differentiation
  • Mice
  • Mice, Inbred C57BL
  • NF-kappa B
  • src-Family Kinases