Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Course of illness, hippocampal function, and hippocampal volume in major depression.

Studies have examined hippocampal function and volume in depressed subjects, but none have systematically compared never-treated first-episode patients with those who have had multiple episodes. We sought to compare hippocampal function, as assessed by performance on hippocampal-dependent recollection memory tests, and hippocampal volumes, as measured in a 1.5-T magnetic resonance imager, in depressed subjects experiencing a postpubertal onset of depression. Twenty never-treated depressed subjects in a first episode of depression were compared with matched healthy control subjects. Seventeen depressed subjects with multiple past episodes of depression were also compared with matched healthy controls and to the first-episode patients. Both first- and multiple-episode depressed groups had hippocampal dysfunction apparent on several tests of recollection memory; only depressed subjects with multiple depressive episodes had hippocampal volume reductions. Curve-fitting analysis revealed a significant logarithmic association between illness duration and hippocampal volume. Reductions in hippocampal volume may not antedate illness onset, but volume may decrease at the greatest rate in the early years after illness onset.

Pubmed ID: 12552118


  • MacQueen GM
  • Campbell S
  • McEwen BS
  • Macdonald K
  • Amano S
  • Joffe RT
  • Nahmias C
  • Young LT


Proceedings of the National Academy of Sciences of the United States of America

Publication Data

February 4, 2003

Associated Grants


Mesh Terms

  • Adult
  • Depressive Disorder
  • Female
  • Hippocampus
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging
  • Male
  • Memory