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Melanopsin (Opn4) requirement for normal light-induced circadian phase shifting.

Science (New York, N.Y.) | Dec 13, 2002

http://www.ncbi.nlm.nih.gov/pubmed/12481141

The master circadian oscillator in the hypothalamic suprachiasmatic nucleus is entrained to the day/night cycle by retinal photoreceptors. Melanopsin (Opn4), an opsin-based photopigment, is a primary candidate for photoreceptor-mediated entrainment. To investigate the functional role of melanopsin in light resetting of the oscillator, we generated melanopsin-null mice (Opn4-/-). These mice entrain to a light/dark cycle and do not exhibit any overt defect in circadian activity rhythms under constant darkness. However, they display severely attenuated phase resetting in response to brief pulses of monochromatic light, highlighting the critical role of melanopsin in circadian photoentrainment in mammals.

Pubmed ID: 12481141 RIS Download

Mesh terms: Animals | Biological Clocks | Circadian Rhythm | Darkness | Female | Gene Targeting | Light | Light Signal Transduction | Male | Mice | Mice, Inbred C57BL | Mice, Knockout | Motor Activity | Retinal Ganglion Cells | Rod Opsins | Suprachiasmatic Nucleus

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Associated grants

  • Agency: NIMH NIH HHS, Id: MH 62405
  • Agency: NIMH NIH HHS, Id: MH51573

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