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ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation.

Molecular cell | Nov 27, 2002

http://www.ncbi.nlm.nih.gov/pubmed/12453419

ALL-1 is a member of the human trithorax/Polycomb gene family and is also involved in acute leukemia. ALL-1 is present within a stable, very large multiprotein supercomplex composed of > or =29 proteins. The majority of the latter are components of the human transcription complexes TFIID (including TBP), SWI/SNF, NuRD, hSNF2H, and Sin3A. Other components are involved in RNA processing or in histone methylation. The complex remodels, acetylates, deacetylates, and methylates nucleosomes and/or free histones. The complex's H3-K4 methylation activity is conferred by the ALL-1 SET domain. Chromatin immunoprecipitations show that ALL-1 and other complex components examined are bound at the promoter of an active ALL-1-dependent Hox a9 gene. In parallel, H3-K4 is methylated, and histones H3 and H4 are acetylated at this promoter.

Pubmed ID: 12453419 RIS Download

Mesh terms: Blotting, Western | Cell Nucleus | Chromatin | DNA-Binding Proteins | HeLa Cells | Histone-Lysine N-Methyltransferase | Histones | Homeodomain Proteins | Humans | K562 Cells | Mass Spectrometry | Methylation | Methyltransferases | Myeloid-Lymphoid Leukemia Protein | Precipitin Tests | Protein Binding | Protein Methyltransferases | Protein Processing, Post-Translational | Protein Structure, Tertiary | Proto-Oncogenes | Silver Staining | Transcription Factors | Transcription, Genetic

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Associated grants

  • Agency: NCI NIH HHS, Id: CA 50507

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