• Register
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.


Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.


Planar polarity and actin dynamics in the epidermis of Drosophila.

Dorsal closure is a morphogenetic process involving the coordinated convergence of two epithelial sheets to enclose the Drosophila melanogaster embryo. Specialized populations of cells at the edges of each epithelial sheet, the dorsal-most epidermal cells, emit actin-based processes that are essential for the proper enclosure of the embryo. Here we show that actin dynamics at the leading edge is preceded by a planar polarization of the dorsal-most epidermal cells associated with a reorganization of the cytoskeleton. An important consequence of this planar polarization is the formation of actin-nucleating centres at the leading edge, which are important in the dynamics of actin. We show that Wingless (Wg) signalling and Jun amino-terminal kinase (JNK) signalling have overlapping but different roles in these events.

Pubmed ID: 12447392


  • Kaltschmidt JA
  • Lawrence N
  • Morel V
  • Balayo T
  • Fern├índez BG
  • Pelissier A
  • Jacinto A
  • Martinez Arias A


Nature cell biology

Publication Data

December 3, 2002

Associated Grants


Mesh Terms

  • Actins
  • Animals
  • Cell Polarity
  • Drosophila Proteins
  • Drosophila melanogaster
  • Embryo, Nonmammalian
  • Epidermis
  • JNK Mitogen-Activated Protein Kinases
  • MAP Kinase Kinase 4
  • Mitogen-Activated Protein Kinase Kinases
  • Morphogenesis
  • Mutation
  • Proto-Oncogene Proteins
  • Signal Transduction
  • Wnt1 Protein