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Planar polarity and actin dynamics in the epidermis of Drosophila.

Nature cell biology | Dec 3, 2002

http://www.ncbi.nlm.nih.gov/pubmed/12447392

Dorsal closure is a morphogenetic process involving the coordinated convergence of two epithelial sheets to enclose the Drosophila melanogaster embryo. Specialized populations of cells at the edges of each epithelial sheet, the dorsal-most epidermal cells, emit actin-based processes that are essential for the proper enclosure of the embryo. Here we show that actin dynamics at the leading edge is preceded by a planar polarization of the dorsal-most epidermal cells associated with a reorganization of the cytoskeleton. An important consequence of this planar polarization is the formation of actin-nucleating centres at the leading edge, which are important in the dynamics of actin. We show that Wingless (Wg) signalling and Jun amino-terminal kinase (JNK) signalling have overlapping but different roles in these events.

Pubmed ID: 12447392 RIS Download

Mesh terms: Actins | Animals | Cell Polarity | Drosophila Proteins | Drosophila melanogaster | Embryo, Nonmammalian | Epidermis | JNK Mitogen-Activated Protein Kinases | MAP Kinase Kinase 4 | Mitogen-Activated Protein Kinase Kinases | Morphogenesis | Mutation | Proto-Oncogene Proteins | Signal Transduction | Wnt1 Protein

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