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A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity.

Nature genetics | Jan 1, 2003

We report a systematic RNA interference (RNAi) screen of 5,690 Caenorhabditis elegans genes for gene inactivations that increase lifespan. We found that genes important for mitochondrial function stand out as a principal group of genes affecting C. elegans lifespan. A classical genetic screen identified a mutation in the mitochondrial leucyl-tRNA synthetase gene (lrs-2) that impaired mitochondrial function and was associated with longer-lifespan. The long-lived worms with impaired mitochondria had lower ATP content and oxygen consumption, but differential responses to free-radical and other stresses. These data suggest that the longer lifespan of C. elegans with compromised mitochrondria cannot simply be assigned to lower free radical production and suggest a more complex coupling of metabolism and longevity.

Pubmed ID: 12447374 RIS Download

Mesh terms: Adenosine Triphosphate | Animals | Caenorhabditis elegans | Gene Expression Regulation | Genes, Helminth | Genetic Testing | Leucine-tRNA Ligase | Longevity | Mitochondria | Oxygen Consumption | RNA Interference | Stress, Physiological

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Associated grants

  • Agency: Wellcome Trust, Id: 054523

WormBase (Data, Gene Expression)

Aging Genes and Interventions Database (Data, Gene Expression)

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