Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Plzf mediates transcriptional repression of HoxD gene expression through chromatin remodeling.

Developmental cell | Oct 31, 2002

http://www.ncbi.nlm.nih.gov/pubmed/12408802

The molecular mechanisms that regulate coordinated and colinear activation of Hox gene expression in space and time remain poorly understood. Here we demonstrate that Plzf regulates the spatial expression of the AbdB HoxD gene complex by binding to regulatory elements required for restricted Hox gene expression and can recruit histone deacetylases to these sites. We show by scanning forced microscopy that Plzf, via homodimerization, can form DNA loops and bridge distant Plzf binding sites located within HoxD gene regulatory elements. Furthermore, we demonstrate that Plzf physically interacts with Polycomb proteins on DNA. We propose a model by which the balance between activating morphogenic signals and transcriptional repressors such as Plzf establishes proper Hox gene expression boundaries in the limb bud.

Pubmed ID: 12408802 RIS Download

Mesh terms: Animals | Chromatin | DNA | DNA-Binding Proteins | Gene Expression Regulation, Developmental | Histones | Homeodomain Proteins | Kruppel-Like Transcription Factors | Mice | Microscopy, Atomic Force | Polycomb-Group Proteins | Repressor Proteins | Transcription Factors | Transcription, Genetic

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

  • Agency: NCI NIH HHS, Id: CA-71692

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.