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Timing requirements for insulin/IGF-1 signaling in C. elegans.

The insulin/IGF-1 (where IGF-1 is insulin-like growth factor-1) signaling pathway influences longevity, reproduction, and diapause in many organisms. Because of the fundamental importance of this system in animal physiology, we asked when during the animal's life it is required to regulate these different processes. We find that in Caenorhabditis elegans, the pathway acts during adulthood, to relatively advanced ages, to influence aging. In contrast, it regulates diapause during development. In addition, the pathway controls longevity and reproduction independently of one another. Together our findings show that life-span regulation can be dissociated temporally from phenotypes that might seem to decrease the quality of life.

Pubmed ID: 12399591


  • Dillin A
  • Crawford DK
  • Kenyon C


Science (New York, N.Y.)

Publication Data

October 25, 2002

Associated Grants

  • Agency: NIA NIH HHS, Id: 5RO1AG11816

Mesh Terms

  • Aging
  • Animals
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • DEAD-box RNA Helicases
  • Insulin
  • Insulin-Like Growth Factor I
  • Life Cycle Stages
  • Longevity
  • Mutation
  • Oxidative Stress
  • RNA Helicases
  • RNA Interference
  • Receptor, Insulin
  • Reproduction
  • Signal Transduction
  • Temperature
  • Transcription Factors