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Potentiation of serum response factor activity by a family of myocardin-related transcription factors.

Myocardin is a SAP (SAF-A/B, Acinus, PIAS) domain transcription factor that associates with serum response factor (SRF) to potently enhance SRF-dependent transcription. Here we describe two myocardin-related transcription factors (MRTFs), A and B, that also interact with SRF and stimulate its transcriptional activity. Whereas myocardin is expressed specifically in cardiac and smooth muscle cells, MRTF-A and -B are expressed in numerous embryonic and adult tissues. In SRF-deficient embryonic stem cells, myocardin and MRTFs are unable to activate SRF-dependent reporter genes, confirming their dependence on SRF. Myocardin and MRTFs comprise a previously uncharacterized family of SRF cofactors with the potential to modulate SRF target genes in a wide range of tissues.

Pubmed ID: 12397177


  • Wang DZ
  • Li S
  • Hockemeyer D
  • Sutherland L
  • Wang Z
  • Schratt G
  • Richardson JA
  • Nordheim A
  • Olson EN


Proceedings of the National Academy of Sciences of the United States of America

Publication Data

November 12, 2002

Associated Grants


Mesh Terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Binding Sites
  • Blotting, Northern
  • Cloning, Molecular
  • DNA, Complementary
  • Expressed Sequence Tags
  • Gene Expression Regulation, Developmental
  • Glutathione Transferase
  • Humans
  • Mice
  • Molecular Sequence Data
  • Myocardium
  • Nuclear Proteins
  • Recombinant Fusion Proteins
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Serum Response Factor
  • Trans-Activators
  • Transcription Factors
  • Xenopus