Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo.

Cell | Oct 4, 2002

http://www.ncbi.nlm.nih.gov/pubmed/12372299

The Period2 gene plays a key role in controlling circadian rhythm in mice. We report here that mice deficient in the mPer2 gene are cancer prone. After gamma radiation, these mice show a marked increase in tumor development and reduced apoptosis in thymocytes. The core circadian genes are induced by gamma radiation in wild-type mice but not in mPer2 mutant mice. Temporal expression of genes involved in cell cycle regulation and tumor suppression, such as Cyclin D1, Cyclin A, Mdm-2, and Gadd45alpha, is deregulated in mPer2 mutant mice. In particular, the transcription of c-myc is controlled directly by circadian regulators and is deregulated in the mPer2 mutant. Our studies suggest that the mPer2 gene functions in tumor suppression by regulating DNA damage-responsive pathways.

Pubmed ID: 12372299 RIS Download

Mesh terms: ARNTL Transcription Factors | Animals | Apoptosis | Basic Helix-Loop-Helix Transcription Factors | Blotting, Northern | Blotting, Western | Cell Cycle | Cell Cycle Proteins | Cell Division | Cyclin A | Cyclin D1 | DNA Damage | Dimerization | Flow Cytometry | Gamma Rays | Genetic Predisposition to Disease | Mice | Mice, Inbred C57BL | Mutation | Neoplasms, Experimental | Nerve Tissue Proteins | Nuclear Proteins | Period Circadian Proteins | Phenotype | Promoter Regions, Genetic | Proto-Oncogene Proteins | Proto-Oncogene Proteins c-mdm2 | Proto-Oncogene Proteins c-myc | Thymus Gland | Time Factors | Transcription Factors | Transfection | Tumor Suppressor Protein p53

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

None

Mouse Genome Informatics (Data, Gene Annotation)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.