Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Genome sequence of the human malaria parasite Plasmodium falciparum.

Nature | Oct 3, 2002

http://www.ncbi.nlm.nih.gov/pubmed/12368864

The parasite Plasmodium falciparum is responsible for hundreds of millions of cases of malaria, and kills more than one million African children annually. Here we report an analysis of the genome sequence of P. falciparum clone 3D7. The 23-megabase nuclear genome consists of 14 chromosomes, encodes about 5,300 genes, and is the most (A + T)-rich genome sequenced to date. Genes involved in antigenic variation are concentrated in the subtelomeric regions of the chromosomes. Compared to the genomes of free-living eukaryotic microbes, the genome of this intracellular parasite encodes fewer enzymes and transporters, but a large proportion of genes are devoted to immune evasion and host-parasite interactions. Many nuclear-encoded proteins are targeted to the apicoplast, an organelle involved in fatty-acid and isoprenoid metabolism. The genome sequence provides the foundation for future studies of this organism, and is being exploited in the search for new drugs and vaccines to fight malaria.

Pubmed ID: 12368864 RIS Download

Mesh terms: Animals | Chromosome Structures | DNA Repair | DNA Replication | DNA, Protozoan | Evolution, Molecular | Genome, Protozoan | Humans | Malaria Vaccines | Malaria, Falciparum | Membrane Transport Proteins | Molecular Sequence Data | Plasmodium falciparum | Plastids | Proteome | Protozoan Proteins | Recombination, Genetic | Sequence Analysis, DNA

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.