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Fragile X-related protein and VIG associate with the RNA interference machinery.

RNA interference (RNAi) is a flexible gene silencing mechanism that responds to double-stranded RNA by suppressing homologous genes. Here, we report the characterization of RNAi effector complexes (RISCs) that contain small interfering RNAs and microRNAs (miRNAs). We identify two putative RNA-binding proteins, the Drosophila homolog of the fragile X mental retardation protein (FMRP), dFXR, and VIG (Vasa intronic gene), through their association with RISC. FMRP, the product of the human fragile X locus, regulates the expression of numerous mRNAs via an unknown mechanism. The possibility that dFXR, and potentially FMRP, use, at least in part, an RNAi-related mechanism for target recognition suggests a potentially important link between RNAi and human disease.

Pubmed ID: 12368260

Authors

  • Caudy AA
  • Myers M
  • Hannon GJ
  • Hammond SM

Journal

Genes & development

Publication Data

October 1, 2002

Associated Grants

  • Agency: NIGMS NIH HHS, Id: R01-GM62534

Mesh Terms

  • Amino Acid Sequence
  • Animals
  • Argonaute Proteins
  • Cell Line
  • Drosophila Proteins
  • Drosophila melanogaster
  • Fragile X Mental Retardation Protein
  • Gene Silencing
  • Insect Proteins
  • MicroRNAs
  • Molecular Sequence Data
  • RNA, Double-Stranded
  • RNA, Small Interfering
  • RNA-Binding Proteins
  • RNA-Induced Silencing Complex