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A cell type-specific allele of the POU gene Oct-6 reveals Schwann cell autonomous function in nerve development and regeneration.

While an important role for the POU domain transcription factor Oct-6 in the developing peripheral nerve has been well established, studies into its exact role in nerve development and regeneration have been hampered by the high mortality rate of newborn Oct-6 mutant animals. In this study we have generated a Schwann cell-specific Oct-6 allele through deletion of the Schwann cell-specific enhancer element (SCE) in the Oct-6 locus. Analysis of mice homozygous for this allele (deltaSCE allele) reveals that rate-limiting levels of Oct-6 in Schwann cells are dependent on the SCE and that this element does not contribute to Oct-6 regulation in other cell types. We demonstrate a Schwann cell autonomous function for Oct-6 during nerve development as well as in regenerating nerve. Additionally, we show that Krox-20, an important regulatory target of Oct-6 in Schwann cells, is activated, with delayed kinetics, through an Oct-6-independent mechanism in these mice.

Pubmed ID: 12198163


  • Ghazvini M
  • Mandemakers W
  • Jaegle M
  • Piirsoo M
  • Driegen S
  • Koutsourakis M
  • Smit X
  • Grosveld F
  • Meijer D


The EMBO journal

Publication Data

September 2, 2002

Associated Grants


Mesh Terms

  • Alleles
  • Animals
  • Cell Lineage
  • Chimera
  • Crosses, Genetic
  • DNA-Binding Proteins
  • Early Growth Response Protein 2
  • Enhancer Elements, Genetic
  • Female
  • Gene Targeting
  • Male
  • Mice
  • Myelin Sheath
  • Nerve Regeneration
  • Nerve Tissue Proteins
  • Octamer Transcription Factor-6
  • Organ Specificity
  • Peripheral Nerves
  • Schwann Cells
  • Sequence Deletion
  • Transcription Factors