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Endosome-associated complex, ESCRT-II, recruits transport machinery for protein sorting at the multivesicular body.

Developmental cell | Aug 26, 2002

http://www.ncbi.nlm.nih.gov/pubmed/12194858

Sorting of ubiquitinated endosomal membrane proteins into the MVB pathway is executed by the class E Vps protein complexes ESCRT-I, -II, and -III, and the AAA-type ATPase Vps4. This study characterizes ESCRT-II, a soluble approximately 155 kDa protein complex formed by the class E Vps proteins Vps22, Vps25, and Vps36. This protein complex transiently associates with the endosomal membrane and thereby initiates the formation of ESCRT-III, a membrane-associated protein complex that functions immediately downstream of ESCRT-II during sorting of MVB cargo. ESCRT-II in turn functions downstream of ESCRT-I, a protein complex that binds to ubiquitinated endosomal cargo. We propose that the ESCRT complexes perform a coordinated cascade of events to select and sort MVB cargoes for delivery to the lumen of the vacuole/lysosome.

Pubmed ID: 12194858 RIS Download

Mesh terms: Carrier Proteins | Cell Membrane | Endosomes | Eukaryotic Cells | Fungal Proteins | Lysosomes | Macromolecular Substances | Membrane Proteins | Protein Binding | Protein Transport | Saccharomyces cerevisiae | Saccharomyces cerevisiae Proteins | Transport Vesicles | Ubiquitin

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Associated grants

  • Agency: NCI NIH HHS, Id: CA58689

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