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Escrt-III: an endosome-associated heterooligomeric protein complex required for mvb sorting.

Developmental cell | Aug 26, 2002

The sorting of transmembrane proteins (e.g., cell surface receptors) into the multivesicular body (MVB) pathway to the lysosomal/vacuolar lumen requires the function of the ESCRT protein complexes. The soluble coiled-coil-containing proteins Vps2, Vps20, Vps24, and Snf7 are recruited from the cytoplasm to endosomal membranes where they oligomerize into a protein complex, ESCRT-III. ESCRT-III contains two functionally distinct subcomplexes. The Vps20-Snf7 subcomplex binds to the endosomal membrane, in part via the myristoyl group of Vps20. The Vps2-Vps24 subcomplex binds to the Vps20-Snf7 complex and thereby serves to recruit additional cofactors to this site of protein sorting. We provide evidence for a role for ESCRT-III in sorting and/or concentration of MVB cargoes.

Pubmed ID: 12194857 RIS Download

Mesh terms: Animals | Carrier Proteins | Cell Compartmentation | Cell Membrane | Endosomal Sorting Complexes Required for Transport | Endosomes | Escherichia coli | Eukaryotic Cells | Fungal Proteins | Lysosomes | Macromolecular Substances | Membrane Proteins | Microscopy, Electron | Mutation | Nuclear Proteins | Peptide Hydrolases | Protein Transport | Saccharomyces cerevisiae | Saccharomyces cerevisiae Proteins | Transport Vesicles | trans-Golgi Network

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Associated grants

  • Agency: NCI NIH HHS, Id: CA58689

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