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Eye suppression, a novel function of teashirt, requires Wingless signaling.

http://www.ncbi.nlm.nih.gov/pubmed/12183379

teashirt (tsh) encodes a Drosophila zinc-finger protein. Misexpression of tsh has been shown to induce ectopic eye formation in the antenna. We report that tsh can suppress eye development. This novel function of tsh is due to the induction of homothorax (hth), a known repressor of eye development, and requires Wingless (WG) signaling. Interestingly, tsh has different functions in the dorsal and ventral eye, suppressing eye development close to the ventral margin, while promoting eye development near the dorsal margin. It affects both growth of eye disc and retinal cell differentiation.

Pubmed ID: 12183379 RIS Download

Mesh terms: Animals | Body Patterning | Cell Differentiation | Cell Division | Drosophila | Drosophila Proteins | Eye | Eye Abnormalities | Gene Expression Regulation, Developmental | Proto-Oncogene Proteins | Repressor Proteins | Signal Transduction | Transcription Factors | Wnt1 Protein | Zinc Fingers

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