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Unmyelinated tactile afferents signal touch and project to insular cortex.

There is dual tactile innervation of the human hairy skin: in addition to fast-conducting myelinated afferent fibers, there is a system of slow-conducting unmyelinated (C) afferents that respond to light touch. In a unique patient lacking large myelinated afferents, we found that activation of C tactile (CT) afferents produced a faint sensation of pleasant touch. Functional magnetic resonance imaging (fMRI) analysis during CT stimulation showed activation of the insular region, but not of somatosensory areas S1 and S2. These findings identify CT as a system for limbic touch that may underlie emotional, hormonal and affiliative responses to caress-like, skin-to-skin contact between individuals.

Pubmed ID: 12145636

Authors

  • Olausson H
  • Lamarre Y
  • Backlund H
  • Morin C
  • Wallin BG
  • Starck G
  • Ekholm S
  • Strigo I
  • Worsley K
  • Vallbo AB
  • Bushnell MC

Journal

Nature neuroscience

Publication Data

September 28, 2002

Associated Grants

None

Mesh Terms

  • Adult
  • Afferent Pathways
  • Brain Mapping
  • Cerebral Cortex
  • Female
  • Functional Laterality
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Mechanoreceptors
  • Middle Aged
  • Nerve Fibers
  • Nerve Fibers, Myelinated
  • Peripheral Nervous System Diseases
  • Physical Stimulation
  • Skin
  • Somatosensory Cortex
  • Touch