We have updated our privacy policy. If you have any question, contact us at privacy@scicrunch.org. Dismiss and don't show again

Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Abnormal spine morphology and enhanced LTP in LIMK-1 knockout mice.

Neuron | Jul 3, 2002

In vitro studies indicate a role for the LIM kinase family in the regulation of cofilin phosphorylation and actin dynamics. In addition, abnormal expression of LIMK-1 is associated with Williams syndrome, a mental disorder with profound deficits in visuospatial cognition. However, the in vivo function of this family of kinases remains elusive. Using LIMK-1 knockout mice, we demonstrate a significant role for LIMK-1 in vivo in regulating cofilin and the actin cytoskeleton. Furthermore, we show that the knockout mice exhibited significant abnormalities in spine morphology and in synaptic function, including enhanced hippocampal long-term potentiation. The knockout mice also showed altered fear responses and spatial learning. These results indicate that LIMK-1 plays a critical role in dendritic spine morphogenesis and brain function.

Pubmed ID: 12123613 RIS Download

Mesh terms: Actin Cytoskeleton | Actin Depolymerizing Factors | Animals | Cell Differentiation | Cells, Cultured | Conditioning (Psychology) | Cytoskeleton | DNA-Binding Proteins | Dendrites | Excitatory Postsynaptic Potentials | Fear | Female | Hippocampus | Lim Kinases | Long-Term Potentiation | Male | Maze Learning | Mice | Mice, Knockout | Microfilament Proteins | Microtubule-Associated Proteins | Motor Activity | Mutation | Nervous System Malformations | Neural Inhibition | Protein Kinases | Protein-Serine-Threonine Kinases | Up-Regulation | Williams Syndrome

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants


Mouse Genome Informatics (Data, Gene Annotation)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

We have not found any resources mentioned in this publication.