An efficient Th1-driven adaptive immune response requires activation of the T cell receptor and secretion of the T cell stimulatory cytokine IL-12 by activated antigen-presenting cells. IL-12 triggers Th1 polarization of naive CD4(+) T cells and secretion of IFN-gamma. We describe a new heterodimeric cytokine termed IL-27 that consists of EBI3, an IL-12p40-related protein, and p28, a newly discovered IL-12p35-related polypeptide. IL-27 is an early product of activated antigen-presenting cells and drives rapid clonal expansion of naive but not memory CD4(+) T cells. It also strongly synergizes with IL-12 to trigger IFN-gamma production of naive CD4(+) T cells. IL-27 mediates its biologic effects through the orphan cytokine receptor WSX-1/TCCR.
Pubmed ID: 12121660 RIS Download
Mesh terms: Amino Acid Sequence | Antigen-Presenting Cells | CD4-Positive T-Lymphocytes | Carrier Proteins | Cell Division | Dimerization | Glutathione Transferase | Glycoproteins | Interferon-gamma | Interleukin-12 | Interleukins | Minor Histocompatibility Antigens | Molecular Sequence Data | Protein Conformation | Receptors, Cytokine | Sequence Alignment | Th1 Cells
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