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IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells.

An efficient Th1-driven adaptive immune response requires activation of the T cell receptor and secretion of the T cell stimulatory cytokine IL-12 by activated antigen-presenting cells. IL-12 triggers Th1 polarization of naive CD4(+) T cells and secretion of IFN-gamma. We describe a new heterodimeric cytokine termed IL-27 that consists of EBI3, an IL-12p40-related protein, and p28, a newly discovered IL-12p35-related polypeptide. IL-27 is an early product of activated antigen-presenting cells and drives rapid clonal expansion of naive but not memory CD4(+) T cells. It also strongly synergizes with IL-12 to trigger IFN-gamma production of naive CD4(+) T cells. IL-27 mediates its biologic effects through the orphan cytokine receptor WSX-1/TCCR.

Pubmed ID: 12121660


  • Pflanz S
  • Timans JC
  • Cheung J
  • Rosales R
  • Kanzler H
  • Gilbert J
  • Hibbert L
  • Churakova T
  • Travis M
  • Vaisberg E
  • Blumenschein WM
  • Mattson JD
  • Wagner JL
  • To W
  • Zurawski S
  • McClanahan TK
  • Gorman DM
  • Bazan JF
  • de Waal Malefyt R
  • Rennick D
  • Kastelein RA



Publication Data

June 17, 2002

Associated Grants


Mesh Terms

  • Amino Acid Sequence
  • Antigen-Presenting Cells
  • CD4-Positive T-Lymphocytes
  • Carrier Proteins
  • Cell Division
  • Dimerization
  • Glutathione Transferase
  • Glycoproteins
  • Interferon-gamma
  • Interleukin-12
  • Interleukins
  • Molecular Sequence Data
  • Protein Conformation
  • Receptors, Cytokine
  • Sequence Alignment
  • Th1 Cells